Fibroblast Electrical Remodeling in Heart Failure and Potential Effects on Atrial Fibrillation
نویسندگان
چکیده
منابع مشابه
Fibroblast electrical remodeling in heart failure and potential effects on atrial fibrillation.
Fibroblasts are activated in heart failure (HF) and produce fibrosis, which plays a role in maintaining atrial fibrillation (AF). The effect of HF on fibroblast ion currents and its potential role in AF are unknown. Here, we used a patch-clamp technique to investigate the effects of HF on atrial fibroblast ion currents, and mathematical computation to assess the potential impact of this remodel...
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OBJECTIVE Atrial remodeling contributes to the maintenance of atrial fibrillation (AF) in several cardiac disorders. There is evidence that angiotensin-converting enzyme (ACE) inhibitors reduce the prevalence of AF in patients with congestive heart failure (CHF). There have been no studies performed to assess the effects of ACE inhibitors on atrial dimensions and emptying function in relationsh...
متن کاملAtrial Electrophysiological Remodeling and Fibrillation in Heart Failure
Heart failure (HF) causes complex, chronic changes in atrial structure and function, which can cause substantial electrophysiological remodeling and predispose the individual to atrial fibrillation (AF). Pharmacological treatments for preventing AF in patients with HF are limited. Improved understanding of the atrial electrical and ionic/molecular mechanisms that promote AF in these patients co...
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Introduction: The present study is aimed to evaluate electrophysiological remodeling of atrioventricular (AV) node and ventricular conduction during experimental atrial fibrillation (AF) model in isolated heart of cirrhotic rats. Methods: Cirrhosis-induced electrophysiological remodeling was evaluated in 24 isolated retrogradely perfused rat hearts in 2 groups (control and cirrhotic). Cirrho...
متن کاملAtrial fibrillation and heart failure.
Atrial fibrillation (AF) and congestive heart failure (CHF) are the new epidemics of the third millennium due to ageing of the population and the success of new therapies for acute cardiac illnesses that, in the past, were fatal. The interactions between AF and CHF are only partially understood, and the effectiveness of drugs as well as that of non-pharmacological interventions remains often di...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.10.014